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The influence of light on the skin immune system
Department of Dermatology, Medical University of Lodz, Poland
The results of numerous in vitro and in vivo studies, performed for over 30 years, indicate that ultraviolet radiation (UVR) has the ability to modulate skin immunity. UVR suppresses contact hypersensitivity response what results from functional impairment of the contact between antigen presenting cells and T lymphocytes. Photoproducts formation, generation of hapten-specific T regulatory cells as well UV-mediated release of various cytokines such as IL-1, IL-6, IL-10 and TNF-α from the epidermal cells also take part in development of photoimmunosuppression. Because of the evident link between excessive exposure to UVR and photoaging and nonmelanoma skin cancers development, it is obligatory for clinicians, especially dermatologists to spread the knowledge on suppressive effects of UVR. In the lecture molecular basis of UVR influence on human immunity will be discussed.
© Joanna Narbutt (text) and Radoslaw Spiewak (source code).
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Document created: 29 August 2009, last updated: 30 August 2009.